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The following articles are given as references only. Original articles must be obtained by the reader via his/her institution library or from the journal publisher.

Chothia, C., Lesk, A.M., Levitt, M., Amit, A.G., Mariuzza, R.A., Phillips, S.E.V. & Poljak, R.J. The Predicted Structure of Immunoglobulin D1.3 and Its Comparison with the Crystal Structure. Science 1986, 233, 755-758

Chothia, C. & Lesk, A.M. Canonical structures for the hypervariable loops of immunoglobulins. J.Mol.Biol. 1987, 196, 901-917

Martin, A.C.R., Cheetham, J.C. & Rees, A.R. (1989) Modeling antibody hypervariable loops: a combined algorithm. Proc.Natl.Acad.Sci.U.S.A. 86, 9268-9272

Webster,D.M., Henry,A.H. & Rees,A.R. (1994) Antibody-antigen interactions. Curr.Opin.Struct.Biol. 4, 123-129

Pedersen,J., Henry,A.H., Searle,S.J., Guild,B.C., Roguska,M. & Rees,AR. Comparison of surface accessible residues in human and murine immunoglobulin Fv domains: implications for humanisation of murine antibodies. 1994 J.Mol.Biol. 235, 959-973

Roguska,M., Pedersen,J., Keddy,C.A., Henry,A.H., Searle,S.J., Lambert,J.M., Blattler,W.A., Rees,A.R. & Guild,B.C. (1994) Humanisation of murine antibodies through variable domain resurfacing. Proc.Natl.Acad.Sci.U.S.A 1, 969-973

Shirai H, Kidera A, Nakamura H. H3-rules: identification of CDR-H3 structures in antibodies. FEBS Lett. 1999, 455(1-2):188-97

Whitelegg NR, Rees AR. WAM: an improved algorithm for modeling antibodies on the WEB. Protein Eng. 2000 Dec;13 (12):819-24.

Tan, P. et al J. Superhumanized" Antibodies: Reduction of Immunogenic Potential by Complementarity- Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD281Immunology, 2002, 169, 1119-1125

Tolcher, A.W. et al. Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. 2003 J. Clin. Oncology 21, 211-222

Whitelegg,N. & Rees, AR Antibody variable Regions: Towards a Unified modeling method. In: Methods in Molecular Biology, Biotechnology and Medicine, (Ed. Lo, B), 2004; 248:51-91.

Helft, P.R. et al. A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors Clin. Cancer Res. 2004, 10, 4363-4368

Pelat, T. et al. Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering.J. Mol. Biol. 2008, 384, 1400-1407

Kuroda D. et al. Structural classification of CDR-H3 revisited: a lesson in antibody modeling. Proteins. 2008 Nov 15;73(3):608-20

Abhinandan & Martin. Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains. 2008, Mol.Immunol. 45: 3832-3839

Marcatili et al. PIGS: automatic prediction of antibody structures. 2008, Bioinformatics (2008) 24 (17): 1953- 1954

Kuroda D. et al. Systematic classification of CDR-L3 in antibodies: implications of the light chain subtypes and the VL-VH interface. Proteins. 2009 Apr;75(1):139-46.

Mader, A. & Kunert, R. Humanization strategies for an anti-idiotypic antibody mimicking HIV-1 gp41Prot.Eng.Des.Selec. 2010, 23, 947-954

Martin, A.C.R. and Allen, J. Bioinformatics tools for antibody engineering. In: Handbook of Therapeutic Antibodies Vol 1 (Technologies) - 2nd Edition, (2013) Ed.: Duebel, S.; Wiley-VCH, Weinheim

Beck, A. et al in, Fourth World Antibody-Drug Conjugate Summit. February 29–March 1, 2012, Frankfurt, Germany. mAbs, 2012, 4, 637–647

Andrew Martin et al,

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